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General Concepts of Histology and Endocrinology authored by Swapan Kumar Rej and published by the New Central Book Agency
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Core Content Overview
The textbook Heredity, Genetics and Genetical Diseases focuses on three interconnected branches of biological sciences:
- Heredity: The mechanism by which traits, characteristics, and genetic information pass down from one generation to the next.
- Genetics: The broader science studying how genes function, mutate, replicate, and map out the features of living organisms.
- Genetical Diseases: The study of clinical disorders, congenital anomalies, and genetic syndromes arising from mutations, structural chromosome damage, or cellular deviations.
Core Curricular Topics Covered
The text is structured around fundamental genetic principles typically aligned with university-level life sciences syllabi:
Mendelian & Molecular Genetics
- Mendelian Principles: Laws of segregation, independent assortment, and dominance.
- DNA & RNA Architecture: Structural mapping, replication loops, transcription, and translation mechanics.
- Gene Regulation: Systems controlling gene expression, such as operon models in prokaryotes and chromatin remodeling in eukaryotes.
Chromosomal Mechanics & Variations
- Cell Division: Detailed pathways of mitosis and meiosis alongside checkpoint controls.
- Chromosomal Aberrations: Structural adjustments (deletions, duplications, inversions) and numerical alterations (aneuploidy and polyploidy).
- Linkage & Mapping: Mechanisms of crossing over, gene mapping, and genetic recombination.
Human Genetics & Clinical Pathologies
- Inheritance Patterns: Autosomal dominant/recessive and sex-linked (X or Y) genetic pathways.
- Genetic Disorders: Etiology and clinical progression of conditions like Down syndrome, sickle cell anemia, and hemophilia.
- Pedigree Analysis: Standardized methods for mapping ancestral charts to identify risk indicators for inherited diseases.
- Biochemical Genetics: Inborn errors of metabolism such as phenylketonuria (PKU).
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