“Molecular Biology” written by R N Roy and published by NCBA (New Central Book Agency).

Name: "Molecular Biology" written by R N Roy and published by NCBA (New Central Book Agency). - Booksbp.com
SKU: 9789352550364
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SKU: 9789352550364

1. General Physiology & Biophysics

This section outlines how physics directly controls cellular functions and biological fluid systems.

Cell Membrane Biophysics: Active, passive, and facilitated transport mechanisms. It details the molecular functions of the Sodium-Potassium Pump (Na⁺/K⁺-ATPase) and Calcium pumps.
Colloidal Properties & Transport: Physical chemistry basics applied to living tissues—including osmotic pressure equations, surface tension, viscosity of blood, and Gibbs-Donnan equilibrium.
Acid-Base Balance: Biochemical blood buffering systems, mapping how the bicarbonate (HCO₃⁻), phosphate, and hemoglobin systems maintain a strict physiological blood pH.

2. Nerve & Muscle Physiology

Focuses on the electrophysiology and mechanical behavior of excitable human tissues.

The Action Potential: The mathematics and ionic currents behind the Resting Membrane Potential (-70mV), depolarization via voltage-gated Na⁺ channels, and repolarization via K⁺ efflux.
Skeletal Muscle Contraction: The biochemical stepping of the Sliding Filament Theory, focusing on cross-bridge cycling, ATP hydrolysis, and the regulatory roles of Troponin and Tropomyosin.
Neuromuscular Transmission: The precise sequence of calcium-dependent acetylcholine (ACh) release at the motor endplate, receptor binding, and subsequent destruction by acetylcholinesterase.

3. Blood & Body Fluids

Analyzes the composition, protective immune properties, and fluid mechanics of human blood.

Hemopoiesis Pathways: Cellular steps of red blood cell differentiation (Erythropoiesis) from pluripotent stem cells, regulated by the hormone erythropoietin.
Coagulation Cascade: Step-by-step breakdown of both the Intrinsic and Extrinsic Clotting Pathways, mapping the activation of Factor X, prothrombin-to-thrombin conversion, and stable fibrin mesh formation.
Hemoglobin & Iron Metabolism: The molecular structure of the hemoglobin tetramer, cooperativity in oxygen binding, and the biochemistry of iron storage (ferritin) and transport (transferrin).

4. Cardiovascular System (CVS)

Traces the mechanics, electrical triggers, and pressure regulations governing blood circulation.

The Cardiac Cycle: Mechanical phases of the heart, detailing intraventricular pressure changes during Isovolumetric Contraction, Ejection, Isovolumetric Relaxation, and Ventricular Filling.
Electrocardiogram (ECG) Tracing: Electrophysiological origin of cardiac wave vectors—the P wave (atrial depolarization), QRS complex (ventricular depolarization), and T wave (ventricular repolarization).
Hemodynamics & Blood Pressure Regulation: Long-term and short-term homeostatic controls, detailing the neural baroreceptor reflex arc alongside the hormonal Renin-Angiotensin-Aldosterone System (RAAS).